1. Round | 18/09/2021 | CF América [] | - | Cruz Azul [] | 4:2 | ||||
2. Round | 25/09/2021 | Cruz Azul [] | - | CF Pachuca [] | 3:6 | ||||
4. Round | 09/10/2021 | FC Juárez [] | - | Cruz Azul [] | 4:3 | ||||
6. Round | 23/10/2021 | Cruz Azul [] | - | CF América [] | 2:2 | ||||
8. Round | 06/11/2021 | Cruz Azul [] | - | Puebla FC [] | 2:2 | ||||
10. Round | 20/11/2021 | Club Tijuana [] | - | Cruz Azul [] | 1:2 |