| 7. Round | 29/08/2021 | Salyut Belgorod | - | Avangard Kursk | 2:1 |  |
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| 9. Round | 11/09/2021 | Avangard Kursk | - | Dinamo Vladivostok | 1:2 | ||||
| 10. Round | 14/09/2021 | Avangard Kursk | - | FK Sakhalin | 2:0 | |
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| 11. Round | 18/09/2021 | Dinamo Bryansk | - | Avangard Kursk | 0:0 |  |
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| 13. Round | 30/09/2021 | FK Kaluga | - | Avangard Kursk | 2:1 | |
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| 14. Round | 04/10/2021 | Arsenal Tula 2 | - | Avangard Kursk | 0:2 | |
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| 15. Round | 10/10/2021 | Zenit Penza | - | Avangard Kursk | 3:1 | ||||
| 19. Round | 31/10/2021 | Avangard Kursk | - | Salyut Belgorod | 1:0 | ||||
| 21. Round | 11/11/2021 | Dinamo Vladivostok | - | Avangard Kursk | 1:1 | ||||
| 22. Round | 14/11/2021 | FK Sakhalin | - | Avangard Kursk | 0:3 |
Russia