| 1. Round | 28/07/2021 | Venados FC | - | Club Celaya | 1:2 | ||||
| 4. Round | 18/08/2021 | Club Celaya | - | Coyotes de Tlaxcala | 3:0 |  |
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| 7. Round | 09/09/2021 | Tepatitlán | - | Club Celaya | 0:1 | ||||
| 10. Round | 29/09/2021 | Correcaminos UAT | - | Club Celaya | 1:0 | ||||
| 11. Round | 06/10/2021 | Club Celaya | - | Cimarrones de Sonora | 1:0 | ||||
| 12. Round | 14/10/2021 | Leones Negros | - | Club Celaya | 1:2 | ||||
| 14. Round | 27/10/2021 | Mineros de Zacatecas | - | Club Celaya | 3:1 | ||||
| 15. Round | 03/11/2021 | Club Celaya | - | Dorados de Sinaloa | 2:2 | ||||
| 16. Round | 12/11/2021 | Tapatío | - | Club Celaya | 1:1 | ||||
| 17. Round | 17/11/2021 | Club Celaya | - | Cancún FC | 3:1 | |
USA
Mexico