| 1. Round | 25/07/2021 | Dynamo České Budějovice | - | FK Teplice | 1:0 | ||||
| 2. Round | 01/08/2021 | 1. FC Slovácko | - | Dynamo České Budějovice | 1:0 | ||||
| 3. Round | 07/08/2021 | Dynamo České Budějovice | - | Baník Ostrava | 1:3 | ||||
| 4. Round | 14/08/2021 | Sigma Olomouc | - | Dynamo České Budějovice | 3:3 | ||||
| 8. Round | 18/09/2021 | Viktoria Plzeň | - | Dynamo České Budějovice | 2:1 | ||||
| 9. Round | 25/09/2021 | Dynamo České Budějovice | - | MFK Karviná | 3:1 | ||||
| 10. Round | 02/10/2021 | Dynamo České Budějovice | - | FK Pardubice | 3:1 | ||||
| 11. Round | 16/10/2021 | FK Jablonec | - | Dynamo České Budějovice | 2:2 | ||||
| 16. Round | 27/11/2021 | Dynamo České Budějovice | - | 1. FC Slovácko | 3:2 |
Czech Republic