| 1. Round | 17/07/2010 | 1. FC Slovácko | - | FK Teplice | 3:0 | ||||
| 2. Round | 24/07/2010 | AC Sparta Praha | - | 1. FC Slovácko | 2:1 | ||||
| 3. Round | 31/07/2010 | 1. FC Slovácko | - | FC Hradec Králové | 2:1 | ||||
| 4. Round | 07/08/2010 | Bohemians 1905 | - | 1. FC Slovácko | 1:0 | ||||
| 9. Round | 18/09/2010 | 1. FK Příbram | - | 1. FC Slovácko | 0:1 | ||||
| 10. Round | 24/09/2010 | 1. FC Slovácko | - | Slavia Praha | 3:0 | ||||
| 11. Round | 02/10/2010 | Baník Ostrava | - | 1. FC Slovácko | 2:1 |  |
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| 12. Round | 18/10/2010 | 1. FC Slovácko | - | Sigma Olomouc | 0:2 | ||||
| 13. Round | 24/10/2010 | Zbrojovka Brno | - | 1. FC Slovácko | 7:0 | ||||
| 14. Round | 31/10/2010 | 1. FC Slovácko | - | Slovan Liberec | 0:1 |  |
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| 19. Round | 05/03/2011 | 1. FC Slovácko | - | Viktoria Plzeň | 2:2 | ||||
| 20. Round | 13/03/2011 | FK Ústí nad Labem | - | 1. FC Slovácko | 2:0 | ||||
| 26. Round | 01/05/2011 | Sigma Olomouc | - | 1. FC Slovácko | 0:2 | ||||
| 28. Round | 14/05/2011 | Slovan Liberec | - | 1. FC Slovácko | 1:0 |  |
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| 29. Round | 21/05/2011 | 1. FC Slovácko | - | FK Mladá Boleslav | 1:2 | ||||
| 30. Round | 28/05/2011 | FK Teplice | - | 1. FC Slovácko | 1:1 | |
Czech Republic