| 3. Round | 05/09/2021 | AS Cannes [Youth] | - | Montpellier HSC [Youth] | 1:1 | ||||
| 5. Round | 19/09/2021 | Toulouse FC [Youth] | - | Montpellier HSC [Youth] | 2:0 | ||||
| 8. Round | 09/10/2021 | Montpellier HSC [Youth] | - | AS Monaco [Youth] | 1:0 | ||||
| 9. Round | 17/10/2021 | US Colomiers [Youth] | - | Montpellier HSC [Youth] | 1:0 | ||||
| 11. Round | 14/11/2021 | Nîmes Olympique [Youth] | - | Montpellier HSC [Youth] | 1:3 | ||||
| 14. Round | 05/12/2021 | Olympique Marseille [Youth] | - | Montpellier HSC [Youth] | 1:2 | ||||
| 16. Round | 22/01/2022 | OGC Nice [Youth] | - | Montpellier HSC [Youth] | 1:2 | ||||
| 18. Round | 13/02/2022 | FC Istres [Youth] | - | Montpellier HSC [Youth] | 1:0 | ||||
| 21. Round | 27/03/2022 | Montpellier HSC [Youth] | - | US Colomiers [Youth] | 0:0 | ||||
| 22. Round | 03/04/2022 | AC Ajaccio [Youth] | - | Montpellier HSC [Youth] | 4:1 | ||||
| 24. Round | 17/04/2022 | Montpellier HSC [Youth] | - | AS Saint-Étienne [Youth] | 2:4 |
Russia