| 5. Round | 20/09/2021 | FC Barcelona | - | Granada CF | 1:1 | ||||
| 6. Round | 23/09/2021 | Cádiz CF | - | FC Barcelona | 0:0 | ||||
| 7. Round | 26/09/2021 | FC Barcelona | - | Levante UD | 3:0 | ||||
| 8. Round | 02/10/2021 | Atlético Madrid | - | FC Barcelona | 2:0 | ||||
| 9. Round | 17/10/2021 | FC Barcelona | - | Valencia CF | 3:1 |  |
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| 10. Round | 24/10/2021 | FC Barcelona | - | Real Madrid | 1:2 | ||||
| 11. Round | 27/10/2021 | Rayo Vallecano | - | FC Barcelona | 1:0 |  |
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| 12. Round | 30/10/2021 | FC Barcelona | - | CD Alavés | 1:1 | ||||
| 14. Round | 20/11/2021 | FC Barcelona | - | Espanyol Barcelona | 1:0 | ||||
| 15. Round | 27/11/2021 | Villarreal CF | - | FC Barcelona | 1:3 | |
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| 16. Round | 04/12/2021 | FC Barcelona | - | Real Betis | 0:1 | ||||
| 17. Round | 12/12/2021 | CA Osasuna | - | FC Barcelona | 2:2 |
Brazil
Portugal 
