| 1. Round | 08/01/2022 | Cruz Azul [U20] | - | Club Tijuana [U20] | 0:1 | ||||
| 6. Round | 18/02/2022 | Club Tijuana [U20] | - | Club Necaxa [U20] | 2:1 | ||||
| 7. Round | 25/02/2022 | Club Tijuana [U20] | - | Atlas Guadalajara [U20] | 2:1 | ||||
| 8. Round | 01/03/2022 | Deportivo Toluca [U20] | - | Club Tijuana [U20] | 3:1 | ||||
| 10. Round | 12/03/2022 | Santos Laguna [U20] | - | Club Tijuana [U20] | 4:2 | ||||
| 11. Round | 18/03/2022 | Club Tijuana [U20] | - | FC Juárez [U20] | 1:1 | ||||
| 14. Round | 15/04/2022 | Club Tijuana [U20] | - | CF América [U20] | 4:0 |  |
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| 15. Round | 19/04/2022 | Deportivo Guadalajara [U20] | - | Club Tijuana [U20] | 1:1 | ||||
| 17. Round | 30/04/2022 | CF Monterrey [U20] | - | Club Tijuana [U20] | 3:0 |
Mexico