| 1. Round | 07/02/2021 | Club Olimpia | - | Libertad | 0:1 | ||||
| 3. Round | 15/02/2021 | Libertad | - | Cerro Porteño | 2:1 | ||||
| 4. Round | 21/02/2021 | Club Nacional | - | Libertad | 0:3 | ||||
| 2. Round | 24/02/2021 | Guaireña FC | - | Libertad | 1:0 |  |
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| 7. Round | 29/03/2021 | Libertad | - | Guaraní | 1:1 | ||||
| 11. Round | 12/04/2021 | Libertad | - | Guaireña FC | 2:1 | ||||
| 14. Round | 04/05/2021 | River Plate | - | Libertad | 1:3 | ||||
| 15. Round | 09/05/2021 | Libertad | - | 12 de Octubre de Itauguá | 3:1 |  |
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| 16. Round | 17/05/2021 | Guaraní | - | Libertad | 1:6 | |
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| 17. Round | 22/05/2021 | Libertad | - | Sol de América | 1:2 | ||||
| 18. Round | 29/05/2021 | Sportivo Luqueño | - | Libertad | 1:3 | |
Paraguay