| 7. Round | 20/03/2022 | Libertad | - | Guaraní | 2:0 | ||||
| 8. Round | 02/04/2022 | Guaireña FC | - | Libertad | 2:3 | ||||
| 10. Round | 17/04/2022 | Cerro Porteño | - | Libertad | 4:0 | ||||
| 11. Round | 21/04/2022 | Libertad | - | Resistencia SC | 2:2 | ||||
| 16. Round | 15/05/2022 | Sportivo Ameliano | - | Libertad | 1:3 | ||||
| 18. Round | 14/06/2022 | Guaraní | - | Libertad | 1:1 | ||||
| 19. Round | 18/06/2022 | Libertad | - | Guaireña FC | 2:0 |  |
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| 20. Round | 21/06/2022 | Sol de América | - | Libertad | 0:3 | ||||
| 22. Round | 03/07/2022 | Resistencia SC | - | Libertad | 0:4 |
Paraguay