| Group F | 16/09/2021 | Crvena Zvezda | - | Sporting Braga | 2:1 | ||||
| Group F | 30/09/2021 | Sporting Braga | - | FC Midtjylland | 3:1 |  |
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| Group F | 21/10/2021 | PFC Ludogorets Razgrad | - | Sporting Braga | 0:1 | |
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| Group F | 04/11/2021 | Sporting Braga | - | PFC Ludogorets Razgrad | 4:2 | ||||
| Group F | 25/11/2021 | FC Midtjylland | - | Sporting Braga | 3:2 | |
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| Group F | 09/12/2021 | Sporting Braga | - | Crvena Zvezda | 1:1 | ||||
| Play-offs | 17/02/2022 | FC Sheriff | - | Sporting Braga | 2:0 | ||||
| Play-offs | 24/02/2022 | Sporting Braga | - | FC Sheriff | 3:2 pso | |
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| Round of 16 | 10/03/2022 | Sporting Braga | - | AS Monaco | 2:0 | ||||
| Round of 16 | 17/03/2022 | AS Monaco | - | Sporting Braga | 1:1 | ||||
| Quarter-finals | 07/04/2022 | Sporting Braga | - | Rangers FC | 1:0 | ||||
| Quarter-finals | 14/04/2022 | Rangers FC | - | Sporting Braga | 3:1 aet |  |
Portugal