1. Round | 17/07/2022 | Club Olimpia | - | Guaraní | 2:0 | ||||
2. Round | 20/07/2022 | Libertad | - | Club Olimpia | 4:2 | ||||
3. Round | 24/07/2022 | Club Olimpia | - | Guaireña FC | 2:1 | ||||
4. Round | 31/07/2022 | Tacuary | - | Club Olimpia | 2:1 | ||||
5. Round | 07/08/2022 | Club Olimpia | - | Sportivo Ameliano | 2:0 | ||||
6. Round | 14/08/2022 | Club Olimpia | - | Cerro Porteño | 2:0 | ||||
7. Round | 20/08/2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
8. Round | 27/08/2022 | Club Olimpia | - | Resistencia SC | 1:1 | ||||
9. Round | 04/09/2022 | 12 de Octubre de Itauguá | - | Club Olimpia | 1:3 | ||||
10. Round | 11/09/2022 | Club Olimpia | - | Sol de América | 2:2 | ||||
11. Round | 16/09/2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
12. Round | 20/09/2022 | Guaraní | - | Club Olimpia | 2:1 | ||||
17. Round | 16/10/2022 | Cerro Porteño | - | Club Olimpia | 1:2 | ||||
18. Round | 22/10/2022 | Club Olimpia | - | General Caballero DJLM | 2:1 | ||||
19. Round | 27/10/2022 | Resistencia SC | - | Club Olimpia | 1:6 | ||||
20. Round | 30/10/2022 | Club Olimpia | - | 12 de Octubre de Itauguá | 3:1 | ||||
21. Round | 08/11/2022 | Sol de América | - | Club Olimpia | 0:2 | ||||
22. Round | 12/11/2022 | Club Olimpia | - | Club Nacional | 1:1 |