1. Round | 17/07/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
2. Round | 21/07/2022 | Club Nacional | - | Resistencia SC | 1:1 | ||||
3. Round | 25/07/2022 | 12 de Octubre de Itauguá | - | Club Nacional | 1:2 | ||||
4. Round | 30/07/2022 | Club Nacional | - | Sol de América | 3:0 | ||||
5. Round | 07/08/2022 | Cerro Porteño | - | Club Nacional | 0:0 | ||||
6. Round | 14/08/2022 | Guaraní | - | Club Nacional | 1:1 | ||||
7. Round | 21/08/2022 | Club Nacional | - | Libertad | 0:2 | ||||
18. Round | 23/10/2022 | Libertad | - | Club Nacional | 0:1 | ||||
19. Round | 27/10/2022 | Club Nacional | - | Guaireña FC | 3:0 |