1. Round | 27/07/2021 | Cruz Azul | - | Mazatlán FC | 0:2 | ||||
4. Round | 15/08/2021 | Club León | - | Mazatlán FC | 3:0 | ||||
5. Round | 17/08/2021 | Deportivo Toluca | - | Mazatlán FC | 2:2 | ||||
6. Round | 21/08/2021 | Mazatlán FC | - | UANL Tigres | 0:3 | ||||
8. Round | 12/09/2021 | CF América | - | Mazatlán FC | 2:0 |