| Group H | 05/06/2021 | Cascavel FC - PR | - | Joinville - SC | 3:3 | ||||
| Group H | 13/06/2021 | Marcílio Dias - SC | - | Cascavel FC - PR | 1:1 |  |
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| Group H | 19/06/2021 | Cascavel FC - PR | - | S.E.R. Caxias - RS | 1:0 | |
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| Group H | 27/06/2021 | Aimoré - RS | - | Cascavel FC - PR | 1:3 | |
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| Group H | 03/07/2021 | Cascavel FC - PR | - | Esportivo - RS | 2:1 | ||||
| Group H | 10/07/2021 | Cascavel FC - PR | - | Juventus - SC | 1:0 | ||||
| Group H | 18/07/2021 | Rio Branco - PR | - | Cascavel FC - PR | 1:4 | |
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| Group H | 24/07/2021 | Cascavel FC - PR | - | Rio Branco - PR | 3:1 | |
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| Group H | 31/07/2021 | Juventus - SC | - | Cascavel FC - PR | 1:1 | |
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| Group H | 07/08/2021 | Esportivo - RS | - | Cascavel FC - PR | 2:2 | ||||
| Group H | 14/08/2021 | Cascavel FC - PR | - | Aimoré - RS | 2:2 | |
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| Group H | 28/08/2021 | Cascavel FC - PR | - | Marcílio Dias - SC | 2:0 | ||||
| Group H | 04/09/2021 | Joinville - SC | - | Cascavel FC - PR | 3:1 | ||||
| Round of 32 | 12/09/2021 | Cianorte - PR | - | Cascavel FC - PR | 0:0 | |
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| Round of 32 | 18/09/2021 | Cascavel FC - PR | - | Cianorte - PR | 0:3 |  |
Brazil