| 1. Round | 08/01/2022 | FC Juárez | - | Club Necaxa | 2:1 | ||||
| 3. Round | 24/01/2022 | Santos Laguna | - | Club Necaxa | 1:4 |  |
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| 4. Round | 05/02/2022 | Club Necaxa | - | CF Pachuca | 1:3 | ||||
| 5. Round | 13/02/2022 | Cruz Azul | - | Club Necaxa | 1:2 | |
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| 8. Round | 02/03/2022 | Mazatlán FC | - | Club Necaxa | 0:0 | ||||
| 9. Round | 05/03/2022 | Club Necaxa | - | Deportivo Toluca | 0:1 | |
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| 10. Round | 12/03/2022 | Club Necaxa | - | Gallos Blancos | 1:0 | ||||
| 11. Round | 19/03/2022 | Pumas UNAM | - | Club Necaxa | 1:3 | |
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| 12. Round | 03/04/2022 | Club Necaxa | - | CF América | 0:1 | ||||
| 13. Round | 08/04/2022 | Atlas Guadalajara | - | Club Necaxa | 2:1 | |
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| 14. Round | 16/04/2022 | Club Necaxa | - | Atlético San Luis | 4:2 | |
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| 15. Round | 20/04/2022 | Club Necaxa | - | UANL Tigres | 2:0 | |
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| 16. Round | 23/04/2022 | Puebla FC | - | Club Necaxa | 0:1 | |
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| 17. Round | 30/04/2022 | Club Necaxa | - | Deportivo Guadalajara | 0:1 |
Uruguay