1. Round | 18/09/2021 | Club Tijuana [] | - | Pumas UNAM [] | 1:2 | ||||
3. Round | 02/10/2021 | Deportivo Toluca [] | - | Club Tijuana [] | 3:0 | ||||
4. Round | 09/10/2021 | Club Tijuana [] | - | Puebla FC [] | 5:0 | ||||
5. Round | 16/10/2021 | CF América [] | - | Club Tijuana [] | 6:0 | ||||
8. Round | 06/11/2021 | FC Juárez [] | - | Club Tijuana [] | 1:1 | ||||
10. Round | 20/11/2021 | Club Tijuana [] | - | Cruz Azul [] | 1:2 |