2. Round | 25/09/2021 | Mazorqueros | - | Leones Negros II | 3:0 | ||||
4. Round | 10/10/2021 | Colima FC | - | Leones Negros II | 2:1 | ||||
5. Round | 13/10/2021 | Correcaminos UAT II | - | Leones Negros II | 1:1 | ||||
7. Round | 23/10/2021 | Mineros de Fresnillo FC | - | Leones Negros II | 0:3 | ||||
11. Round | 13/11/2021 | Saltillo FC | - | Leones Negros II | 3:1 | ||||
13. Round | 27/11/2021 | Catedráticos Elite | - | Leones Negros II | 3:2 |