| 2. Round | 19/09/2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 | ||||
| 5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
| 6. Round | 17/10/2021 | PAOK Saloniki | - | Volos NFC | 4:4 | ||||
| 7. Round | 24/10/2021 | Olympiakos Piraeus | - | PAOK Saloniki | 2:1 | ||||
| 8. Round | 30/10/2021 | PAOK Saloniki | - | Apollon Smyrnis | 4:1 | ||||
| 9. Round | 07/11/2021 | Panathinaikos | - | PAOK Saloniki | 1:3 | ||||
| 10. Round | 21/11/2021 | Atromitos | - | PAOK Saloniki | 2:0 | ||||
| 16. Round | 12/01/2022 | PAOK Saloniki | - | Panetolikos | 2:0 |  |
Brazil
