1. Round | 25/07/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
2. Round | 01/08/2021 | CF Monterrey | - | Pumas UNAM | 2:0 | ||||
3. Round | 08/08/2021 | Pumas UNAM | - | Atlético San Luis | 1:3 | ||||
8. Round | 12/09/2021 | Pumas UNAM | - | Deportivo Guadalajara | 0:0 | ||||
9. Round | 19/09/2021 | Mazatlán FC | - | Pumas UNAM | 2:2 | ||||
10. Round | 26/09/2021 | UANL Tigres | - | Pumas UNAM | 0:0 | ||||
12. Round | 03/10/2021 | CF América | - | Pumas UNAM | 2:0 | ||||
13. Round | 17/10/2021 | Pumas UNAM | - | FC Juárez | 1:0 |