| 3. Round | 01/08/2021 | Avangard Kursk | - | Zenit Penza | 4:0 | ||||
| 4. Round | 07/08/2021 | Sokol Saratov | - | Avangard Kursk | 3:1 | ||||
| 5. Round | 15/08/2021 | Avangard Kursk | - | FK Ryazan | 0:3 | ||||
| 6. Round | 20/08/2021 | Fakel Voronezh 2 | - | Avangard Kursk | 1:2 | ||||
| 10. Round | 14/09/2021 | Avangard Kursk | - | FK Sakhalin | 2:0 |  |
|||
| 11. Round | 18/09/2021 | Dinamo Bryansk | - | Avangard Kursk | 0:0 | ||||
| 12. Round | 26/09/2021 | Avangard Kursk | - | Dinamo Bryansk | 4:4 | |
|||
| 13. Round | 30/09/2021 | FK Kaluga | - | Avangard Kursk | 2:1 | |
|||
| 14. Round | 04/10/2021 | Arsenal Tula 2 | - | Avangard Kursk | 0:2 | ||||
| 15. Round | 10/10/2021 | Zenit Penza | - | Avangard Kursk | 3:1 | ||||
| 17. Round | 19/10/2021 | FK Ryazan | - | Avangard Kursk | 1:0 | |
|||
| 22. Round | 14/11/2021 | FK Sakhalin | - | Avangard Kursk | 0:3 |
Russia