| 2. Round | 14/08/2021 | FC Vizela [Youth] | - | CD Tondela [Youth] | 1:3 |  |
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| 3. Round | 21/08/2021 | CD Tondela [Youth] | - | Paços de Ferreira [Youth] | 3:2 | ||||
| 4. Round | 29/08/2021 | FC Porto [Youth] | - | CD Tondela [Youth] | 5:0 | ||||
| 7. Round | 26/09/2021 | CD Tondela [Youth] | - | FC Famalicão [Youth] | 1:1 | ||||
| 8. Round | 02/10/2021 | Rio Ave FC [Youth] | - | CD Tondela [Youth] | 1:2 |  |
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| 9. Round | 17/10/2021 | Leixões SC [Youth] | - | CD Tondela [Youth] | 4:2 | ||||
| 10. Round | 23/10/2021 | CD Tondela [Youth] | - | UD Oliveirense [Youth] | 1:1 | ||||
| 11. Round | 30/10/2021 | Gil Vicente [Youth] | - | CD Tondela [Youth] | 3:2 | ||||
| 18. Round | 18/12/2021 | FC Famalicão [Youth] | - | CD Tondela [Youth] | 1:0 | ||||
| 19. Round | 08/01/2022 | CD Tondela [Youth] | - | Rio Ave FC [Youth] | 1:3 | ||||
| 20. Round | 15/01/2022 | CD Tondela [Youth] | - | Leixões SC [Youth] | 3:1 | ||||
| 21. Round | 22/01/2022 | UD Oliveirense [Youth] | - | CD Tondela [Youth] | 0:3 | ||||
| 22. Round | 29/01/2022 | CD Tondela [Youth] | - | Gil Vicente [Youth] | 0:0 |
Portugal
Albania