| 1. Round | 19/09/2004 | Panathinaikos | - | Ionikos Nikea | 3:0 | ||||
| 2. Round | 25/09/2004 | Panathinaikos | - | Skoda Xanthi | 3:1 |  |
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| 3. Round | 03/10/2004 | Apollon Kalamarias | - | Panathinaikos | 0:1 | ||||
| 4. Round | 16/10/2004 | Panathinaikos | - | AO Egaleo | 0:0 | ||||
| 5. Round | 24/10/2004 | AO Kerkyra | - | Panathinaikos | 2:0 |  |
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| 6. Round | 30/10/2004 | Panathinaikos | - | Panionios GSS | 4:0 | |
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| 7. Round | 07/11/2004 | Iraklis Saloniki | - | Panathinaikos | 0:4 | ||||
| 8. Round | 20/11/2004 | Panathinaikos | - | GS Kallithea | 1:0 | ||||
| 9. Round | 28/11/2004 | Aris Saloniki | - | Panathinaikos | 1:1 | ||||
| 10. Round | 04/12/2004 | Olympiakos Piraeus | - | Panathinaikos | 1:0 | |
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| 11. Round | 12/12/2004 | Panathinaikos | - | Ergotelis | 1:0 | ||||
| 12. Round | 19/12/2004 | Atromitos | - | Panathinaikos | 0:2 | ||||
| 13. Round | 29/12/2004 | Panathinaikos | - | PAOK Saloniki | 2:1 | ||||
| 14. Round | 09/01/2005 | AEK Athen | - | Panathinaikos | 1:0 | ||||
| 16. Round | 23/01/2005 | Ionikos Nikea | - | Panathinaikos | 0:0 | ||||
| 20. Round | 27/02/2005 | Panathinaikos | - | AO Kerkyra | 1:0 |
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