| Group E | 22/10/2020 | PSV Eindhoven | - | Granada CF | 1:2 |  |
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| Group E | 29/10/2020 | Granada CF | - | PAOK Saloniki | 0:0 | ||||
| Group E | 05/11/2020 | Omonia Nikosia | - | Granada CF | 0:2 | ||||
| Group E | 26/11/2020 | Granada CF | - | Omonia Nikosia | 2:1 | ||||
| Group E | 03/12/2020 | Granada CF | - | PSV Eindhoven | 0:1 | ||||
| Round of 32 | 18/02/2021 | Granada CF | - | SSC Napoli | 2:0 | |
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| Round of 32 | 25/02/2021 | SSC Napoli | - | Granada CF | 2:1 | ||||
| Round of 16 | 11/03/2021 | Granada CF | - | Molde FK | 2:0 | ||||
| Round of 16 | 18/03/2021 | Molde FK | - | Granada CF | 2:1 | ||||
| Quarter-finals | 08/04/2021 | Granada CF | - | Manchester United | 0:2 | ||||
| Quarter-finals | 15/04/2021 | Manchester United | - | Granada CF | 2:0 |
Portugal