| 1. Round | 20/07/2021 | CF Pachuca [Women] | - | Club Tijuana [Women] | 0:0 | ||||
| 2. Round | 27/07/2021 | Club Tijuana [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 3. Round | 03/08/2021 | Santos Laguna [Women] | - | Club Tijuana [Women] | 0:0 | ||||
| 5. Round | 16/08/2021 | Pumas UNAM [Women] | - | Club Tijuana [Women] | 1:2 | ||||
| 6. Round | 24/08/2021 | Club Tijuana [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 7. Round | 29/08/2021 | Atlético San Luis [Women] | - | Club Tijuana [Women] | 1:3 | ||||
| 9. Round | 12/09/2021 | CF Monterrey [Women] | - | Club Tijuana [Women] | 4:0 | ||||
| 10. Round | 28/09/2021 | UANL Tigres [Women] | - | Club Tijuana [Women] | 3:0 |  |
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| 11. Round | 05/10/2021 | Club Tijuana [Women] | - | Atlas Guadalajara [Women] | 1:2 | ||||
| 13. Round | 19/10/2021 | CF América [Women] | - | Club Tijuana [Women] | 2:0 | ||||
| 16. Round | 16/11/2021 | Club Tijuana [Women] | - | Cruz Azul [Women] | 4:1 | ||||
| 17. Round | 20/11/2021 | FC Juárez [Women] | - | Club Tijuana [Women] | 2:4 |
Mexico