| 1. Round | 23/07/2021 | AS Trenčín | - | Zlaté Moravce | 4:0 | ||||
| 2. Round | 31/07/2021 | Slovan Bratislava | - | AS Trenčín | 2:0 |  |
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| 3. Round | 07/08/2021 | MFK Zemplín Michalovce | - | AS Trenčín | 1:2 | ||||
| 4. Round | 13/08/2021 | AS Trenčín | - | MFK Ružomberok | 1:1 | ||||
| 5. Round | 22/08/2021 | FC DAC 1904 | - | AS Trenčín | 1:1 |  |
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| 6. Round | 28/08/2021 | AS Trenčín | - | ŠKF Sereď | 0:0 | ||||
| 7. Round | 11/09/2021 | MŠK Žilina | - | AS Trenčín | 1:3 | |
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| 8. Round | 18/09/2021 | AS Trenčín | - | FK Senica | 3:3 | ||||
| 9. Round | 24/09/2021 | FK Pohronie | - | AS Trenčín | 2:2 | ||||
| 10. Round | 03/10/2021 | AS Trenčín | - | Spartak Trnava | 0:1 | ||||
| 11. Round | 15/10/2021 | Tatran Liptovský Mikuláš | - | AS Trenčín | 2:1 | ||||
| 12. Round | 23/10/2021 | Zlaté Moravce | - | AS Trenčín | 0:1 |  |
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| 13. Round | 31/10/2021 | AS Trenčín | - | Slovan Bratislava | 2:3 | ||||
| 14. Round | 05/11/2021 | AS Trenčín | - | MFK Zemplín Michalovce | 4:2 | ||||
| 15. Round | 19/11/2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | |
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| 16. Round | 27/11/2021 | AS Trenčín | - | FC DAC 1904 | 0:1 | ||||
| 17. Round | 04/12/2021 | ŠKF Sereď | - | AS Trenčín | 4:2 | ||||
| 18. Round | 11/12/2021 | AS Trenčín | - | MŠK Žilina | 1:3 | ||||
| 19. Round | 18/12/2021 | FK Senica | - | AS Trenčín | 1:0 |
Slovakia