| 1. Round | 16/07/2022 | AS Trenčín | - | MŠK Žilina | 0:0 | ||||
| 2. Round | 23/07/2022 | Slovan Bratislava | - | AS Trenčín | 4:0 | ||||
| 3. Round | 30/07/2022 | MFK Skalica | - | AS Trenčín | 2:0 | ||||
| 4. Round | 05/08/2022 | AS Trenčín | - | MFK Zemplín Michalovce | 3:1 | ||||
| 5. Round | 13/08/2022 | MFK Ružomberok | - | AS Trenčín | 0:0 | ||||
| 6. Round | 20/08/2022 | AS Trenčín | - | Tatran Liptovský Mikuláš | 2:1 | ||||
| 7. Round | 27/08/2022 | FC DAC 1904 | - | AS Trenčín | 1:2 | ||||
| 8. Round | 30/08/2022 | AS Trenčín | - | Dukla Banská Bystrica | 0:2 |  |
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| 9. Round | 03/09/2022 | Zlaté Moravce | - | AS Trenčín | 1:0 | ||||
| 10. Round | 11/09/2022 | AS Trenčín | - | Spartak Trnava | 0:2 | ||||
| 11. Round | 17/09/2022 | FK Železiarne Podbrezová | - | AS Trenčín | 2:0 | ||||
| 12. Round | 01/10/2022 | MŠK Žilina | - | AS Trenčín | 1:1 | ||||
| 13. Round | 09/10/2022 | AS Trenčín | - | Slovan Bratislava | 4:0 | ||||
| 14. Round | 15/10/2022 | AS Trenčín | - | MFK Skalica | 3:1 | ||||
| 15. Round | 22/10/2022 | MFK Zemplín Michalovce | - | AS Trenčín | 2:0 | ||||
| 16. Round | 29/10/2022 | AS Trenčín | - | MFK Ružomberok | 0:0 | |
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| 17. Round | 05/11/2022 | Tatran Liptovský Mikuláš | - | AS Trenčín | 1:1 | |
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| 18. Round | 12/11/2022 | AS Trenčín | - | FC DAC 1904 | 0:4 |
Slovakia