| 4. Round | 28/08/2021 | Vendée Les Herbiers | - | FC Nantes B | 4:3 | ||||
| 6. Round | 11/09/2021 | FC Chamalières | - | FC Nantes B | 2:2 | ||||
| 3. Round | 02/10/2021 | FC Nantes B | - | Angers SCO B | 1:1 | ||||
| 10. Round | 23/10/2021 | FC Nantes B | - | Canet Roussillon | 1:2 | ||||
| 19. Round | 18/02/2022 | Montpellier HSC B | - | FC Nantes B | 0:0 | ||||
| 18. Round | 26/02/2022 | FC Nantes B | - | Vendée Les Herbiers | 1:3 |  |
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| 20. Round | 05/03/2022 | FC Nantes B | - | FC Chamalières | 2:1 | |
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| 21. Round | 11/03/2022 | Andrézieux-Bouthéon FC | - | FC Nantes B | 3:1 | |
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| 22. Round | 19/03/2022 | FC Nantes B | - | US Colomiers | 2:1 | |
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| 23. Round | 02/04/2022 | Bergerac Périgord FC | - | FC Nantes B | 2:0 | ||||
| 25. Round | 16/04/2022 | FC Nantes B | - | Angoulême CFC | 0:0 | ||||
| 26. Round | 23/04/2022 | Trélissac FC | - | FC Nantes B | 1:0 | ||||
| 27. Round | 30/04/2022 | FC Nantes B | - | Moulins Yzeure Foot | 0:1 | ||||
| 28. Round | 14/05/2022 | AS Béziers | - | FC Nantes B | 4:2 | ||||
| 29. Round | 21/05/2022 | FC Nantes B | - | Stade Montois | 2:2 | |
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| 30. Round | 28/05/2022 | Bourges Foot 18 | - | FC Nantes B | 2:1 |
Equatorial Guinea