| 1. Round | 17/07/2021 | Pumas UNAM [Women] | - | Club Necaxa [Women] | 0:0 | ||||
| 2. Round | 26/07/2021 | Club Necaxa [Women] | - | CF Pachuca [Women] | 1:2 | ||||
| 6. Round | 23/08/2021 | Club Necaxa [Women] | - | Puebla FC [Women] | 1:0 |  |
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| 8. Round | 06/09/2021 | Deportivo Toluca [Women] | - | Club Necaxa [Women] | 0:1 | ||||
| 9. Round | 13/09/2021 | Club Necaxa [Women] | - | Mazatlán FC [Women] | 3:0 | ||||
| 10. Round | 28/09/2021 | Club León [Women] | - | Club Necaxa [Women] | 1:1 | ||||
| 11. Round | 04/10/2021 | Club Necaxa [Women] | - | Gallos Blancos [Women] | 2:0 | ||||
| 12. Round | 09/10/2021 | Atlas Guadalajara [Women] | - | Club Necaxa [Women] | 1:0 |  |
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| 13. Round | 18/10/2021 | Club Necaxa [Women] | - | CF Monterrey [Women] | 1:6 | ||||
| 14. Round | 01/11/2021 | Club Necaxa [Women] | - | Club Tijuana [Women] | 1:2 | ||||
| 15. Round | 06/11/2021 | Cruz Azul [Women] | - | Club Necaxa [Women] | 1:0 | ||||
| 16. Round | 13/11/2021 | Club Necaxa [Women] | - | FC Juárez [Women] | 3:1 | |
Mexico