1. Round | 12/01/2022 | Santos Laguna [U18] | - | UANL Tigres [U18] | 5:0 | ||||
2. Round | 16/01/2022 | Deportivo Toluca [U18] | - | Santos Laguna [U18] | 2:2 | ||||
3. Round | 23/01/2022 | Santos Laguna [U18] | - | Club Necaxa [U18] | 1:2 | ||||
4. Round | 06/02/2022 | Atlas Guadalajara [U18] | - | Santos Laguna [U18] | 2:1 | ||||
5. Round | 12/02/2022 | Santos Laguna [U18] | - | CF América [U18] | 2:2 | ||||
7. Round | 27/02/2022 | Cruz Azul [U18] | - | Santos Laguna [U18] | 1:2 | ||||
8. Round | 02/03/2022 | Santos Laguna [U18] | - | Pumas UNAM [U18] | 0:0 | ||||
9. Round | 05/03/2022 | Deportivo Guadalajara [U18] | - | Santos Laguna [U18] | 1:1 | ||||
13. Round | 26/03/2022 | CF Monterrey [U18] | - | Santos Laguna [U18] | 1:2 | ||||
15. Round | 19/04/2022 | Mazatlán FC [U18] | - | Santos Laguna [U18] | 1:2 | ||||
16. Round | 24/04/2022 | Santos Laguna [U18] | - | Club León [U18] | 2:3 | ||||
17. Round | 01/05/2022 | Atlético San Luis [U18] | - | Santos Laguna [U18] | 0:1 |