| 1. Round | 05/02/2017 | Universidad Católica | - | San Luis | 1:0 |  |
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| 2. Round | 10/02/2017 | San Luis | - | Deportes Iquique | 2:3 | ||||
| 3. Round | 19/02/2017 | San Luis | - | Everton | 1:1 | ||||
| 4. Round | 26/02/2017 | Santiago Wanderers | - | San Luis | 0:3 |  |
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| 5. Round | 05/03/2017 | San Luis | - | Antofagasta | 0:5 | ||||
| 6. Round | 11/03/2017 | Universidad de Concepción | - | San Luis | 3:0 | |
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| 7. Round | 17/03/2017 | San Luis | - | Palestino | 2:2 | |
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| 8. Round | 02/04/2017 | Huachipato | - | San Luis | 3:2 | ||||
| 9. Round | 09/04/2017 | San Luis | - | Audax Italiano | 1:0 | |
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| 10. Round | 13/04/2017 | Cobresal | - | San Luis | 1:2 | |
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| 11. Round | 23/04/2017 | San Luis | - | Colo-Colo | 1:0 | |
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| 13. Round | 06/05/2017 | San Luis | - | Deportes Temuco | 1:1 | ||||
| 14. Round | 14/05/2017 | San Luis | - | Unión Española | 3:2 | ||||
| 15. Round | 20/05/2017 | Universidad de Chile | - | San Luis | 1:0 | |
Uruguay