| 20. Round | 27/02/2022 | FC Biel/Bienne | - | FC Chiasso | 1:3 | ||||
| 22. Round | 12/03/2022 | FC Basel 1893 II | - | FC Biel/Bienne | 1:3 | ||||
| 23. Round | 20/03/2022 | FC Biel/Bienne | - | FC Sion II | 1:3 | ||||
| 24. Round | 26/03/2022 | Etoile Carouge FC | - | FC Biel/Bienne | 2:0 | ||||
| 25. Round | 03/04/2022 | FC Biel/Bienne | - | FC Zürich II | 0:1 | ||||
| 26. Round | 06/04/2022 | FC Breitenrain Bern | - | FC Biel/Bienne | 2:4 | ||||
| 27. Round | 10/04/2022 | FC Biel/Bienne | - | SC Brühl | 2:2 |  |
|||
| 28. Round | 16/04/2022 | SC YF/Juventus Zürich | - | FC Biel/Bienne | 1:1 | ||||
| 29. Round | 23/04/2022 | FC Biel/Bienne | - | SC Cham | 3:4 | ||||
| 30. Round | 30/04/2022 | FC Black Stars Basel | - | FC Biel/Bienne | 0:1 |  |
France