| 1. Round | 07/08/2021 | FC Black Stars Basel | - | FC Basel 1893 II | 3:2 |  |
|||
| 10. Round | 09/10/2021 | Etoile Carouge FC | - | FC Basel 1893 II | 2:1 | ||||
| 11. Round | 16/10/2021 | FC Basel 1893 II | - | FC Zürich II | 1:1 | ||||
| 12. Round | 23/10/2021 | FC Breitenrain Bern | - | FC Basel 1893 II | 2:1 | ||||
| 13. Round | 30/10/2021 | FC Basel 1893 II | - | SC Brühl | 1:3 |  |
|||
| 15. Round | 13/11/2021 | FC Basel 1893 II | - | SC Cham | 3:4 | ||||
| 16. Round | 20/11/2021 | FC Basel 1893 II | - | FC Black Stars Basel | 0:1 | ||||
| 17. Round | 27/11/2021 | FC Bavois | - | FC Basel 1893 II | 2:0 | ||||
| 18. Round | 04/12/2021 | FC Basel 1893 II | - | FC Stade Nyonnais | 0:6 | ||||
| 20. Round | 27/02/2022 | BSC Young Boys II | - | FC Basel 1893 II | 1:1 | ||||
| 21. Round | 06/03/2022 | FC Chiasso | - | FC Basel 1893 II | 2:0 | ||||
| 22. Round | 12/03/2022 | FC Basel 1893 II | - | FC Biel/Bienne | 1:3 | ||||
| 23. Round | 19/03/2022 | FC Basel 1893 II | - | FC Rapperswil-Jona | 1:3 | ||||
| 24. Round | 26/03/2022 | FC Sion II | - | FC Basel 1893 II | 1:2 |  |
|||
| 26. Round | 06/04/2022 | FC Zürich II | - | FC Basel 1893 II | 4:2 |
Switzerland