| 1. Round | 09/01/2021 | Puebla FC | - | Deportivo Guadalajara | 1:1 | ||||
| 5. Round | 09/02/2021 | Club León | - | Deportivo Guadalajara | 1:3 | ||||
| 7. Round | 23/02/2021 | CF Pachuca | - | Deportivo Guadalajara | 1:1 | ||||
| 10. Round | 07/03/2021 | Mazatlán FC | - | Deportivo Guadalajara | 1:1 | ||||
| 11. Round | 15/03/2021 | Deportivo Guadalajara | - | CF América | 0:3 | ||||
| 14. Round | 11/04/2021 | Cruz Azul | - | Deportivo Guadalajara | 1:0 | ||||
| 15. Round | 18/04/2021 | Deportivo Guadalajara | - | Club Tijuana | 2:0 | ||||
| 12. Round | 22/04/2021 | CF Monterrey | - | Deportivo Guadalajara | 1:2 | ||||
| 16. Round | 25/04/2021 | Atlas Guadalajara | - | Deportivo Guadalajara | 0:1 | ||||
| 17. Round | 01/05/2021 | Deportivo Guadalajara | - | UANL Tigres | 0:0 |
Mexico