| 1. Round | 10/01/2022 | Deportivo Guadalajara | - | Mazatlán FC | 3:0 | ||||
| 2. Round | 16/01/2022 | CF Pachuca | - | Deportivo Guadalajara | 2:1 | ||||
| 3. Round | 22/01/2022 | Deportivo Guadalajara | - | Gallos Blancos | 1:1 |  |
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| 4. Round | 10/02/2022 | FC Juárez | - | Deportivo Guadalajara | 1:3 | ||||
| 5. Round | 12/02/2022 | Deportivo Guadalajara | - | UANL Tigres | 1:3 | ||||
| 6. Round | 20/02/2022 | Club León | - | Deportivo Guadalajara | 2:1 | ||||
| 7. Round | 27/02/2022 | Deportivo Guadalajara | - | Puebla FC | 2:3 | ||||
| 8. Round | 03/03/2022 | Atlético San Luis | - | Deportivo Guadalajara | 2:2 | |
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| 9. Round | 06/03/2022 | Deportivo Guadalajara | - | Santos Laguna | 1:0 | ||||
| 10. Round | 13/03/2022 | Deportivo Guadalajara | - | CF América | 0:0 | ||||
| 11. Round | 21/03/2022 | Atlas Guadalajara | - | Deportivo Guadalajara | 1:1 | |
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| 13. Round | 10/04/2022 | Deportivo Toluca | - | Deportivo Guadalajara | 1:1 | ||||
| 12. Round | 14/04/2022 | Deportivo Guadalajara | - | CF Monterrey | 1:3 | ||||
| 14. Round | 17/04/2022 | Cruz Azul | - | Deportivo Guadalajara | 0:1 | ||||
| 15. Round | 20/04/2022 | Deportivo Guadalajara | - | Club Tijuana | 2:1 | ||||
| 17. Round | 30/04/2022 | Club Necaxa | - | Deportivo Guadalajara | 0:1 |
Mexico