| 3. Round | 22/01/2021 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 4. Round | 29/01/2021 | Mazatlán FC [U20] | - | CF Pachuca [U20] | 1:3 | ||||
| 5. Round | 07/02/2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 6. Round | 12/02/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 1:0 | ||||
| 8. Round | 26/02/2021 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 3:1 | ||||
| 9. Round | 03/03/2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 2:2 | ||||
| 11. Round | 13/03/2021 | UANL Tigres [U20] | - | Mazatlán FC [U20] | 2:1 | ||||
| 13. Round | 02/04/2021 | Puebla FC [U20] | - | Mazatlán FC [U20] | 6:2 | ||||
| 14. Round | 11/04/2021 | Club Tijuana [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 15. Round | 16/04/2021 | Mazatlán FC [U20] | - | Atlas Guadalajara [U20] | 2:2 | ||||
| 16. Round | 23/04/2021 | Mazatlán FC [U20] | - | Club León [U20] | 1:3 | ||||
| 17. Round | 01/05/2021 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 2:0 |
Mexico