| 22. Round | 16/01/2022 | AS Roma | - | Cagliari Calcio | 1:0 |  |
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| 23. Round | 23/01/2022 | Empoli FC | - | AS Roma | 2:4 | |
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| 24. Round | 05/02/2022 | AS Roma | - | Genoa CFC | 0:0 | ||||
| 25. Round | 13/02/2022 | Sassuolo Calcio | - | AS Roma | 2:2 | ||||
| 26. Round | 19/02/2022 | AS Roma | - | Hellas Verona | 2:2 | |
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| 28. Round | 05/03/2022 | AS Roma | - | Atalanta | 1:0 | ||||
| 29. Round | 13/03/2022 | Udinese Calcio | - | AS Roma | 1:1 | ||||
| 30. Round | 20/03/2022 | AS Roma | - | Lazio Roma | 3:0 | |
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| 31. Round | 03/04/2022 | Sampdoria | - | AS Roma | 0:1 | |
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| 32. Round | 10/04/2022 | AS Roma | - | US Salernitana 1919 | 2:1 | ||||
| 33. Round | 18/04/2022 | SSC Napoli | - | AS Roma | 1:1 | ||||
| 34. Round | 23/04/2022 | Inter | - | AS Roma | 3:1 | |
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| 36. Round | 09/05/2022 | ACF Fiorentina | - | AS Roma | 2:0 | ||||
| 38. Round | 20/05/2022 | Torino FC | - | AS Roma | 0:3 |
Portugal
