| 5. Round | 07/08/2022 | Club Olimpia | - | Sportivo Ameliano | 2:0 |  |
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| 6. Round | 14/08/2022 | Club Olimpia | - | Cerro Porteño | 2:0 | ||||
| 7. Round | 20/08/2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
| 8. Round | 27/08/2022 | Club Olimpia | - | Resistencia SC | 1:1 | ||||
| 9. Round | 04/09/2022 | 12 de Octubre de Itauguá | - | Club Olimpia | 1:3 | ||||
| 10. Round | 11/09/2022 | Club Olimpia | - | Sol de América | 2:2 | ||||
| 11. Round | 16/09/2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
| 12. Round | 20/09/2022 | Guaraní | - | Club Olimpia | 2:1 | ||||
| 15. Round | 06/10/2022 | Club Olimpia | - | Tacuary | 1:0 | ||||
| 16. Round | 09/10/2022 | Sportivo Ameliano | - | Club Olimpia | 0:2 | ||||
| 13. Round | 12/10/2022 | Club Olimpia | - | Libertad | 1:0 | ||||
| 17. Round | 16/10/2022 | Cerro Porteño | - | Club Olimpia | 1:2 | ||||
| 19. Round | 27/10/2022 | Resistencia SC | - | Club Olimpia | 1:6 | |
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| 20. Round | 30/10/2022 | Club Olimpia | - | 12 de Octubre de Itauguá | 3:1 | ||||
| 22. Round | 12/11/2022 | Club Olimpia | - | Club Nacional | 1:1 |
Colombia