1. Round | 11/09/2021 | Cerro Largo | - | Nacional | 0:3 dec. | ||||
2. Round | 19/09/2021 | Nacional | - | Progreso | 0:1 | ||||
3. Round | 25/09/2021 | Sud América | - | Nacional | 0:2 | ||||
4. Round | 03/10/2021 | Nacional | - | Plaza Colonia | 2:1 | ||||
6. Round | 16/10/2021 | Nacional | - | Boston River | 3:2 | ||||
7. Round | 22/10/2021 | Montevideo Wanderers | - | Nacional | 1:0 |