| 2. Round | 31/07/2022 | RFC Seraing | - | KV Kortrijk | 0:1 |  |
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| 3. Round | 07/08/2022 | RSC Anderlecht | - | RFC Seraing | 3:1 | ||||
| 4. Round | 13/08/2022 | RFC Seraing | - | Sporting Charleroi | 0:1 | ||||
| 5. Round | 19/08/2022 | KAS Eupen | - | RFC Seraing | 1:3 | ||||
| 6. Round | 27/08/2022 | RFC Seraing | - | KRC Genk | 0:4 | |
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| 7. Round | 03/09/2022 | KV Mechelen | - | RFC Seraing | 2:3 | ||||
| 8. Round | 10/09/2022 | RFC Seraing | - | Club Brugge KV | 0:2 | |
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| 12. Round | 14/10/2022 | KVC Westerlo | - | RFC Seraing | 2:2 | ||||
| 13. Round | 18/10/2022 | RFC Seraing | - | Cercle Brugge | 0:1 | |
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| 14. Round | 23/10/2022 | KAA Gent | - | RFC Seraing | 2:1 | ||||
| 15. Round | 30/10/2022 | RFC Seraing | - | Union Saint-Gilloise | 1:2 |  |
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| 17. Round | 11/11/2022 | Oud-Heverlee Leuven | - | RFC Seraing | 5:0 | |
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| 18. Round | 23/12/2022 | RFC Seraing | - | KAS Eupen | 0:1 |
France
Guadeloupe