| 1. Round | 07/08/2021 | SC Cham | - | FC Sion II | 2:1 | ||||
| 2. Round | 18/08/2021 | Etoile Carouge FC | - | SC Cham | 0:0 | ||||
| 3. Round | 21/08/2021 | SC Cham | - | FC Zürich II | 3:0 | ||||
| 4. Round | 28/08/2021 | FC Breitenrain Bern | - | SC Cham | 1:1 | ||||
| 5. Round | 04/09/2021 | SC Cham | - | SC Brühl | 0:1 | ||||
| 6. Round | 11/09/2021 | SC YF/Juventus Zürich | - | SC Cham | 4:2 | ||||
| 7. Round | 19/09/2021 | SC Cham | - | FC Rapperswil-Jona | 1:2 | ||||
| 8. Round | 25/09/2021 | SC Cham | - | FC Black Stars Basel | 2:1 | ||||
| 9. Round | 02/10/2021 | FC Bavois | - | SC Cham | 1:4 |  |
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| 11. Round | 16/10/2021 | AC Bellinzona | - | SC Cham | 2:1 | ||||
| 12. Round | 23/10/2021 | SC Cham | - | BSC Young Boys II | 1:3 | ||||
| 16. Round | 20/11/2021 | FC Sion II | - | SC Cham | 3:4 |
France