| 1. Round | 25/06/2022 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 1:0 | ||||
| 2. Round | 02/07/2022 | Club Tijuana [U16] | - | Santos Laguna [U16] | 1:2 |  |
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| 3. Round | 09/07/2022 | Santos Laguna [U16] | - | CF Monterrey [U16] | 3:1 | |
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| 4. Round | 16/07/2022 | Atlético San Luis [U16] | - | Santos Laguna [U16] | 3:2 | ||||
| 5. Round | 23/07/2022 | Santos Laguna [U16] | - | Mazatlán FC [U16] | 2:1 | |
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| 7. Round | 06/08/2022 | Atlas Guadalajara [U16] | - | Santos Laguna [U16] | 1:2 | |
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| 8. Round | 13/08/2022 | Santos Laguna [U16] | - | UANL Tigres [U16] | 1:0 | |
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| 10. Round | 27/08/2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 1:0 | ||||
| 11. Round | 03/09/2022 | Santos Laguna [U16] | - | Club León [U16] | 5:1 | |
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| 13. Round | 17/09/2022 | Santos Laguna [U16] | - | Atlas Guadalajara [U16] | 1:0 | |
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| 15. Round | 01/10/2022 | Mazatlán FC [U16] | - | Santos Laguna [U16] | 0:4 | |
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| 16. Round | 08/10/2022 | Santos Laguna [U16] | - | Atlético San Luis [U16] | 4:0 |
Mexico