| 2. Round | 30/08/1980 | FC Basel 1893 | - | CS Chênois | 0:0 | ||||
| 3. Round | 06/09/1980 | CS Chênois | - | FC Sion | 0:0 | ||||
| 5. Round | 20/09/1980 | CS Chênois | - | Servette FC | 2:2 | ||||
| 6. Round | 04/10/1980 | FC Luzern | - | CS Chênois | 2:1 | ||||
| 7. Round | 08/10/1980 | FC St. Gallen | - | CS Chênois | 2:0 | ||||
| 8. Round | 11/10/1980 | CS Chênois | - | AC Bellinzona | 2:1 | ||||
| 9. Round | 18/10/1980 | FC Nordstern Basel | - | CS Chênois | 1:2 | ||||
| 10. Round | 25/10/1980 | CS Chênois | - | Lausanne Sports | 1:4 | ||||
| 11. Round | 15/11/1980 | BSC Young Boys | - | CS Chênois | 1:1 | ||||
| 12. Round | 22/11/1980 | CS Chênois | - | Grasshopper Club Zürich | 1:3 | ||||
| 19. Round | 11/04/1981 | CS Chênois | - | FC Luzern | 0:0 | ||||
| 22. Round | 09/05/1981 | Lausanne Sports | - | CS Chênois | 4:1 | ||||
| 24. Round | 23/05/1981 | Grasshopper Club Zürich | - | CS Chênois | 2:1 |
England