| 1. Round | 28/02/2021 | Tokyo Verdy | - | Ehime FC | 3:0 | ||||
| 2. Round | 07/03/2021 | Ehime FC | - | JEF United Chiba | 1:1 | ||||
| 3. Round | 13/03/2021 | V-Varen Nagasaki | - | Ehime FC | 1:1 | ||||
| 4. Round | 21/03/2021 | Ehime FC | - | Ventforet Kofu | 0:1 | ||||
| 5. Round | 28/03/2021 | Tochigi SC | - | Ehime FC | 2:1 | ||||
| 6. Round | 04/04/2021 | Ehime FC | - | Thespakusatsu Gunma | 1:2 | ||||
| 7. Round | 11/04/2021 | Ehime FC | - | Fagiano Okayama | 2:2 | ||||
| 8. Round | 17/04/2021 | RB Omiya Ardija | - | Ehime FC | 0:1 | ||||
| 9. Round | 21/04/2021 | Ehime FC | - | Matsumoto Yamaga | 3:1 | ||||
| 10. Round | 24/04/2021 | Ehime FC | - | Albirex Niigata | 0:2 | ||||
| 11. Round | 01/05/2021 | Kyoto Sanga FC | - | Ehime FC | 3:2 | ||||
| 13. Round | 08/05/2021 | Ehime FC | - | FC Ryūkyū | 1:1 | ||||
| 14. Round | 16/05/2021 | Montedio Yamagata | - | Ehime FC | 1:0 | ||||
| 15. Round | 27/05/2021 | SC Sagamihara | - | Ehime FC | 0:1 | ||||
| 16. Round | 30/05/2021 | Ehime FC | - | Mito HollyHock | 0:5 | ||||
| 17. Round | 05/06/2021 | Renofa Yamaguchi | - | Ehime FC | 2:2 | ||||
| 18. Round | 13/06/2021 | Ehime FC | - | Zweigen Kanazawa | 1:3 | ||||
| 19. Round | 20/06/2021 | Giravanz Kitakyushu | - | Ehime FC | 0:2 |
Japan