| 2. Round | 01/08/2021 | Zlaté Moravce | - | MŠK Žilina | 0:1 | ||||
| 4. Round | 15/08/2021 | Tatran Liptovský Mikuláš | - | MŠK Žilina | 2:1 | ||||
| 5. Round | 22/08/2021 | MŠK Žilina | - | FK Senica | 3:0 | ||||
| 6. Round | 29/08/2021 | Spartak Trnava | - | MŠK Žilina | 1:1 | ||||
| 7. Round | 11/09/2021 | MŠK Žilina | - | AS Trenčín | 1:3 | ||||
| 8. Round | 19/09/2021 | Slovan Bratislava | - | MŠK Žilina | 2:2 | ||||
| 9. Round | 25/09/2021 | MŠK Žilina | - | MFK Ružomberok | 0:2 | ||||
| 10. Round | 02/10/2021 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:0 | ||||
| 15. Round | 20/11/2021 | MŠK Žilina | - | Tatran Liptovský Mikuláš | 2:2 | ||||
| 16. Round | 30/11/2021 | FK Senica | - | MŠK Žilina | 2:2 | ||||
| 17. Round | 05/12/2021 | MŠK Žilina | - | Spartak Trnava | 0:1 |
Nigeria
Portugal