| 1. Round | 27/06/2021 | Sport Recife - PE [U20] | - | Santos FC [U20] | 0:1 | ||||
| 2. Round | 30/06/2021 | Santos FC [U20] | - | Grêmio Porto Alegre [U20] | 2:5 | ||||
| 3. Round | 05/07/2021 | Palmeiras [U20] | - | Santos FC [U20] | 2:1 | ||||
| 4. Round | 11/07/2021 | Santos FC [U20] | - | Chapecoense [U20] | 1:1 | ||||
| 5. Round | 14/07/2021 | Ceará - CE [U20] | - | Santos FC [U20] | 2:1 |  |
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| 6. Round | 18/07/2021 | Santos FC [U20] | - | Fortaleza - CE [U20] | 0:0 | |
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| 7. Round | 25/07/2021 | Athletico Paranaense [U20] | - | Santos FC [U20] | 3:2 | ||||
| 8. Round | 28/07/2021 | Santos FC [U20] | - | São Paulo FC [U20] | 1:3 | |
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| 10. Round | 08/08/2021 | Fluminense RJ [U20] | - | Santos FC [U20] | 4:3 | ||||
| 11. Round | 15/08/2021 | Santos FC [U20] | - | Atlético Mineiro [U20] | 0:3 | ||||
| 12. Round | 22/08/2021 | Botafogo - RJ [U20] | - | Santos FC [U20] | 1:1 |  |
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| 13. Round | 29/08/2021 | Santos FC [U20] | - | América - MG [U20] | 1:1 | ||||
| 14. Round | 04/09/2021 | Internacional [U20] | - | Santos FC [U20] | 4:0 | ||||
| 17. Round | 26/09/2021 | Santos FC [U20] | - | Flamengo RJ [U20] | 1:0 |
Brazil