| 3. Round | 19/08/2022 | Willem II | - | Telstar | 2:1 | ||||
| 4. Round | 29/08/2022 | FC Utrecht (J) | - | Willem II | 0:0 |  |
|||
| 5. Round | 02/09/2022 | Willem II | - | ADO Den Haag | 1:0 | ||||
| 6. Round | 09/09/2022 | PEC Zwolle | - | Willem II | 2:2 | ||||
| 7. Round | 16/09/2022 | Willem II | - | AZ Alkmaar (J) | 1:0 | ||||
| 10. Round | 07/10/2022 | Willem II | - | FC Den Bosch | 1:2 | ||||
| 14. Round | 04/11/2022 | Willem II | - | Heracles Almelo | 1:2 | ||||
| 16. Round | 20/11/2022 | FC Dordrecht | - | Willem II | 2:2 | ||||
| 17. Round | 11/12/2022 | Willem II | - | NAC Breda | 1:2 |
Belgium