| 3. Round | 07/08/2021 | Grasshopper Club Zürich | - | FC Lausanne-Sport | 3:1 | ||||
| 12. Round | 31/10/2021 | FC Lausanne-Sport | - | FC Luzern | 1:1 | ||||
| 29. Round | 09/04/2022 | BSC Young Boys | - | FC Lausanne-Sport | 2:2 | ||||
| 30. Round | 18/04/2022 | FC Lausanne-Sport | - | FC Lugano | 4:1 | ||||
| 31. Round | 24/04/2022 | Grasshopper Club Zürich | - | FC Lausanne-Sport | 3:1 | ||||
| 32. Round | 01/05/2022 | FC Luzern | - | FC Lausanne-Sport | 3:0 | ||||
| 34. Round | 12/05/2022 | FC Zürich | - | FC Lausanne-Sport | 2:2 | ||||
| 35. Round | 19/05/2022 | FC Lausanne-Sport | - | FC Sion | 1:2 | ||||
| 36. Round | 22/05/2022 | FC St. Gallen | - | FC Lausanne-Sport | 4:0 |  |
Switzerland