| 2. Round | 12/09/2021 | Doxa Katokopias | - | Anorthosis Famagusta | 2:0 |  |
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| 5. Round | 02/10/2021 | Paphos FC | - | Doxa Katokopias | 1:1 | ||||
| 6. Round | 18/10/2021 | Doxa Katokopias | - | Aris Limassol | 1:2 |  |
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| 7. Round | 22/10/2021 | Olympiakos Nikosia | - | Doxa Katokopias | 1:0 | ||||
| 8. Round | 30/10/2021 | Doxa Katokopias | - | APOEL Nikosia | 2:2 | ||||
| 9. Round | 05/11/2021 | Apollon Limassol | - | Doxa Katokopias | 3:0 | ||||
| 10. Round | 21/11/2021 | Doxa Katokopias | - | AEL Limassol | 0:0 | ||||
| 11. Round | 27/11/2021 | PAEEK | - | Doxa Katokopias | 1:2 | |
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| 12. Round | 04/12/2021 | Doxa Katokopias | - | AEK Larnaca | 1:4 | ||||
| 13. Round | 13/12/2021 | Anorthosis Famagusta | - | Doxa Katokopias | 2:0 | ||||
| 15. Round | 03/01/2022 | Ethnikos Achna | - | Doxa Katokopias | 0:1 | ||||
| 18. Round | 23/01/2022 | Doxa Katokopias | - | Olympiakos Nikosia | 0:0 | ||||
| 19. Round | 30/01/2022 | APOEL Nikosia | - | Doxa Katokopias | 2:0 |  |
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| 20. Round | 07/02/2022 | Doxa Katokopias | - | Apollon Limassol | 0:3 | ||||
| 21. Round | 15/02/2022 | AEL Limassol | - | Doxa Katokopias | 3:2 | ||||
| 16. Round | 18/02/2022 | Doxa Katokopias | - | Paphos FC | 1:1 | ||||
| 22. Round | 27/02/2022 | Doxa Katokopias | - | PAEEK | 1:0 |
Benin