| 1. Round | 12/08/2018 | Vitesse | - | FC Groningen | 5:1 | ||||
| 2. Round | 17/08/2018 | FC Groningen | - | Willem II | 0:1 | ||||
| 3. Round | 25/08/2018 | De Graafschap | - | FC Groningen | 0:1 | ||||
| 5. Round | 15/09/2018 | AFC Ajax | - | FC Groningen | 3:0 | ||||
| 7. Round | 30/09/2018 | FC Groningen | - | FC Utrecht | 1:1 | ||||
| 8. Round | 06/10/2018 | ADO Den Haag | - | FC Groningen | 1:0 | ||||
| 12. Round | 11/11/2018 | FC Groningen | - | sc Heerenveen | 2:0 | ||||
| 14. Round | 02/12/2018 | FC Groningen | - | NAC Breda | 5:2 | ||||
| 15. Round | 09/12/2018 | VVV-Venlo | - | FC Groningen | 0:0 | ||||
| 18. Round | 19/01/2019 | FC Groningen | - | Heracles Almelo | 3:0 | ||||
| 20. Round | 02/02/2019 | Willem II | - | FC Groningen | 1:2 | ||||
| 21. Round | 10/02/2019 | FC Groningen | - | Vitesse | 2:1 | ||||
| 24. Round | 03/03/2019 | FC Groningen | - | VVV-Venlo | 3:2 | ||||
| 28. Round | 02/04/2019 | FC Groningen | - | De Graafschap | 1:0 | ||||
| 29. Round | 06/04/2019 | FC Groningen | - | SBV Excelsior | 1:0 | ||||
| 34. Round | 12/05/2019 | FC Groningen | - | Fortuna Sittard | 3:0 | ||||
| 33. Round | 15/05/2019 | FC Emmen | - | FC Groningen | 1:0 |
Netherlands